The Vermont State Police Bureau of Criminal Investigation is taking the lead of this case; and there are several detectives following up on financial information and checking potential locations where she may have gone.
On Friday, Holmes told her husband, Steven M. St. Peter, that she was going to tend to animals on their farm around 8 a.m. When he woke up around 10 a.m., there was a note on the butcher block that said she went for a ride.
"(It said) she'd see me later on Friday afternoon. She said, 'I love you,' but I haven't heard from her ever since," said St. Peter, who was the last person who has claimed to have seen her.
Holmes is 5'9 and weighs 170 pounds. She has blonde hair and green eyes.
Investigators are speaking to friends and family, while still actively looking for her vehicle, a maroon 2010 Subaru Forester with license plates that read DAK316, registered in Vermont and due to expire in 2015.
The police are concerned for her safety due to the fact she hasn't reached out to family or friends since Friday.
Police initially received a request for a welfare check on Sept. 6 at 2 p.m., as Holmes did not arrive for a scheduled appointment.
Over the weekend, the State Police completed several searches of the Plumb Road area near the residence, and checked other personally significant locations. Police also monitored Holmes' cell phone, social media and financial activity ... all with no results.
Holmes is a registered nurse at Grace Cottage Hospital. She was scheduled for work on Monday but did not show up. The hospital posted information about her being missing. The post also stated that she is a beloved nurse "responsible for arranging for the miniature horses to come to visit a Hospice patient at Grace Cottage last year."
St. Peter told the Reformer that Holmes had won many awards during horse shows and there are currently four horses on their farm.
One of her daughters lives in Townshend, while the other lives in North Carolina. Both women grew up in the area, where Holmes has been a resident for over 30 years.
Anyone who has seen or heard from Helen Holmes since the morning of the Sept. 6 is encouraged to contact the Vermont State Police at the Brattleboro Barracks at 802-254-2382. Or submit an anonymous an anonymous tip by texting "CRIMES" (274637) with keyword: VTIPS or online at http://vsp.vermont.gov/tipsubmit.
Chris Mays can be reached at 802-254-2311, ext. 273, or firstname.lastname@example.org. Follow Chris on Twitter @CMaysReformer.